THE LXR-IDOL AXIS DEFINES A CLATHRIN-, CAVEOLAE-, AND DYNAMIN-INDEPENDENT ENDOCYTIC ROUTE FOR LDLR INTERNALIZATION AND LYSOSOMAL DEGRADATION

The LXR-IDOL axis defines a clathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation

Low density lipoprotein (LDL) cholesterol is taken up into cells via clathrin-mediated endocytosis of the LDL receptor (LDLR).Following dissociation of the LDLR-LDL complex, LDL is directed to lysosomes whereas the LDLR recycles to the plasma membrane.Activation of the sterol-sensing nuclear receptors liver X receptors (LXRs) enhances degradation o

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Scientific support for preparing an EU position in the 46th Session of the Codex Committee on Pesticide Residues (CCPR)

In accordance with Article 43 of Regulation (EC) No 396/2005, EFSA received Blazers a request from the European Commission to provide support for the preparation of the EU position for 46th session of the Codex Committee on Pesticide Residues (CCPR).In 2013, JMPR evaluated 10 active substances regarding the setting of toxicological reference values

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Occurrence of Colibacillosis in Broilers and Its Relationship With Avian Pathogenic Escherichia coli (APEC) Population Structure and Molecular Characteristics

Avian pathogenic Escherichia coli (APEC) causes colibacillosis, the disease with the highest economic loss for the broiler industry.However, studies focusing on the prevalence and population structure of APEC in the broiler production pyramid are scarce.Here, we used genotyping and serotyping data to elucidate the APEC population structure and its

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Problem of urban planning for sustainable development

The article deals with the problems of transformation of St.Petersburg industrial territories including the impressive number of monuments of industrial architecture.The work objective: to trace the application of various methods Mattress Overlays of transformation - reconstruction, restoration and new construction - by way of examples of St.Peters

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Ethnomedicinal information in garuda purana

Objective: The objective of the study is to appraise the contribution of ancient Indian mythological literature in Ayurveda science.Data Source: The information has been gathered from ancient Indian literature Garuda Bar Collar Purana, Ayurveda classical texts, and modern literature related to medicinal plants used in Ayurveda system of medicine.Re

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